MACS GMP Recombinant Human IL-15

MACS GMP Recombinant Human IL-15

Interleukin 15 (IL-15) is a potent lymphoid cell growth factor and stimulates the proliferation of activated T cells and the generation of cytotoxic T lymphocytes (CTLs). IL-15 also induces the generation, activation, and proliferation of NK cells.
MACS GMP Recombinant Human IL-15 is designed for
ex vivo
cell culture processing. No animal- or human-derived materials were used for the manufacture of this product, unless otherwise stated in the respective Certificate of Origin. The product is lyophilized without carrier protein or preservatives.

Disclaimer

MACS GMP Products are for research use and
ex vivo
cell culture processing only, and are not intended for human
in vivo
applications. For regulatory status in the USA, please contact your local representative.

Background information

IL-15 is a member of the four α-helix bundle cytokine family. It is produced by different cell types, including epithelial cells, monocytes, muscle and placenta cells. In addition to its ability to activate T cells and NK cells, IL-15 is also important for B cell growth and immunoglobulin production as well as for the maintenance of CD8
+
memory T cells. For binding and signaling IL-15 uses the unique IL-15 receptor α-chain, but shares the β- and γ-chain of the IL-2 receptor.

Applications

MACS GMP Recombinant Human IL-15 can be used for a variety of applications, including the
ex vivo
generation of cytotoxic T lymphocytes
2,3
or the
ex vivo
stimulation of NK cells
4,5
.

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.

Biological activity

  • The specific activity is determined by proliferation assay according to Soman
    et al.1
    using CTLL-2 cells. The proliferation assay was calibrated with the reference standard for human IL-15 (NIBSC code 95/554) provided by the National Institute for Biological Standards and Control.
  • Specific activity: ≥ 7×
    10
    6
    U/mg
Product options: 1

Product information

Size
Order no.
Price

MACS GMP Recombinant Human IL-15

  • E. coli
  • For research use and
    ex vivo
    cell processing only
25 µg
170-076-114
-