MACS GMP PepTivator® Mucin-1

MACS GMP PepTivator
®
Mucin-1

The MACS GMP PepTivator Mucin-1 is a peptide pool that consists mainly of 15-mer peptides. It has been developed for efficient
in vitro
stimulation and subsequent isolation of Mucin-1-specific CD4
+
and CD8
+
T cells.

Disclaimer

MACS GMP Products are for research use and
ex vivo
cell culture processing only, and are not intended for human
in vivo
applications. For regulatory status in the USA, please contact your local representative.

Background information

Mucin-1 is expressed on epithelial cells in different mucosal tissue like lung, stomach, breast or pancreas. The overexpression is associated with Adenocarcinoma, Lymphoma and Multiple Myeloma and is used as serological clinical marker of breast cancer. This makes Mucin-1 to an attractive target for anticancer immunotherapy.

Applications

The MACS GMP PepTivator Mucin-1 is used for
in vitro
stimulation of Mucin-1-effector and memory T cells. The secretion of IFN-gamma permits the enrichment of Mucin-1-specific CD4
+
and CD8
+
T cells with the use of the CliniMACS Cytokine Capture System (IFN-gamma).
Adoptive transfer of Mucin-1-specific T cells or vaccination with Mucin-1-pulsed dendritic cells may be an effective tool for the treatment of Mucin-1-expressing malignancies.

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
  • Certificates of Analysis (CoA)

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Product information

Size
Order no.
Price

MACS GMP PepTivator Mucin-1

  • For research use and
    ex vivo
    cell processing only
for
stimulation of
10
9
cells
170-076-151
-

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