CD45 antibodies

CD45 antibodies

Clone: REA747
REA747 recognizes the human CD45 antigen, a member of the protein tyrosine phosphatase (PTP) family, also known as the leukocyte common antigen (LCA). The CD45 molecule a type I transmembrane protein which is required for T and B cell activation and involved in cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 is expressed in different isoforms (CD45RA, CD45RB, CD45RC, CD45RAB, CD45RAC, CD45RBC, CD45RO, CD45R (ABC)) depending on the differentiation status of the cell. The CD45 antibody recognizes a common epitope of all CD45 isoforms. Additional information: Clone REA747 displays negligible binding to Fc receptors.

Applications

Reagent can be used for immunophenotyping by flow cytometry. Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis.
Expression of CD45 may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia.

Alternative Names

Ptprc, GP180, L-CA, LY5, T200

Technical specifications

  • Antigen: CD45
  • Clone: REA747
  • Isotype: recombinant human IgG1
  • Alternative names of antigen: Ptprc, GP180, L-CA, LY5, T200
  • Molecular mass of antigen [kDa]: 145
  • Distribution of antigen: B cells, basophils, dendritic cells, granulocytes, hematopoietic cells, Langerhans cells, leukocytes, lymphocytes, macrophages, mast cells, monocytes, plasma cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBlue, VioGreen
  • Certificates of Analysis (CoA)

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Product options: 2

Product information

Size
Order no.
Price

CD45-VioBlue

  • REA747
  • CE–IVD
for 100
tests
170-080-018
-

CD45-VioGreen

  • REA747
  • CE–IVD
for 100
tests
170-080-019
-