CD34 antibodies

CD34 antibodies

Clone: AC136
AC136 recognizes the human CD34, a class III epitope of the CD34 antigen. This epitope is different than the one recognized by the clone used in the CD34 MicroBead Kits. The CD34 antigen is a single-chain transmembrane glycoprotein, expressed on human hematopoietic stem and progenitor cells, endothelial progenitor cells, vascular endothelial cells, embryonic fibroblasts, and some cells in fetal and adult nervous tissue. The antigen is absent on fully differentiated hematopoietic cells, such as normal peripheral blood lymphocytes, monocytes, granulocytes, erythrocytes, and platelets. Clone AC136 has a similar specificity as the CD34 monoclonal antibody clone 8G12 (HPCA-2). CD34 antibodies can be used for studies of hematopoiesis and nonhematopoietic stem cells, phenotyping of hematopoietic stem cells, and studies on phenotyping of hematologic malignancies, endothelial cells, and endothelial progenitor cells (EPCs).

Applications

Reagent can be used for immunophenotyping by flow cytometry. Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis.
Expression of CD34 may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia.

Alternative Names

gp105-120, Mucosialin, My10

Technical specifications

  • Antigen: CD34
  • Clone: AC136
  • Isotype: mouse IgG2aκ
  • Alternative names of antigen: gp105-120, Mucosialin, My10
  • Molecular mass of antigen [kDa]: 37
  • Distribution of antigen: bone marrow, cancer stem cells, CNS cells, dendritic cells, endothelial cells, fibroblasts, hematopoietic stem cells, liver, mast cells, osteoblasts
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBlue
  • Certificates of Analysis (CoA)

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Product information

Size
Order no.
Price

CD34-VioBlue

  • AC136
  • CE–IVD
for 100
tests
170-080-023
-