CD300e antibodies

CD300e antibodies

Clone: UP-H2
The monoclonal antibody UP-H2 reacts with human CD300e, also known as IREM-2, LMIR6, or CMRF35-A5. This 34 kDa activating receptor of the immunglobulin superfamily is expressed on mature myeloid dendritic cells and monocytes and is down-regulated on immature dendritic cells. CD300e interacts with DAP-12, which mediates acivating signals. It is reported that the alloreactive response of naive T cells is enhanced by IREM-2 activation of mDCs.

Applications

Reagent can be used for immunophenotyping by flow cytometry. Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis.
Expression of CD300e may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia.

Technical specifications

  • Antigen: CD300e
  • Clone: UP-H2
  • Isotype: mouse IgG1κ
  • Distribution of antigen: dendritic cells, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
Product options: 1

Product information

Size
Order no.
Price

CD300e-APC

  • UP-H2
  • CE–IVD
for 100
tests
170-078-066
-