CD22 antibodies

CD22 antibodies

Clone: REA340
Clone REA340 recognizes the human CD22 antigen, a single-pass type I membrane protein which is also known as sialic acid-binding Ig-like lectin 2 (Siglec-2). In peripheral blood, cell surface expression of CD22 is found on mature B cells, but is lost during terminal differentiation to plasma cells. In bone marrow, surface expression of CD22 can be detected from the pre–B cell stage on. Cytoplasmic expression of CD22 can also be found in late pro–B cells and early–B cells. CD22 plays a strong role in cell interactions and B cell activation. It is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. CD22 has emerged as an ideal target for monoclonal antibody based therapy of B cell malignancies including most lymphomas and many leukemias.
Additional information: Clone REA340 displays negligible binding to Fc receptors.

Applications

Reagent can be used for immunophenotyping by flow cytometry. Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis.
Expression of CD22 may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia.

Alternative Names

SIGLEC-2, B-lymphocyte cell adhesion molecule (BL-CAM), Sialic acid-binding Ig-like lectin 2 (Siglec-2)

Technical specifications

  • Antigen: CD22
  • Clone: REA340
  • Isotype: recombinant human IgG1
  • Alternative names of antigen: SIGLEC-2, B-lymphocyte cell adhesion molecule (BL-CAM), Sialic acid-binding Ig-like lectin 2 (Siglec-2)
  • Molecular mass of antigen [kDa]: 93
  • Distribution of antigen: B cells, bone marrow
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, VioBlue
  • Certificates of Analysis (CoA)

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Product options: 2

Product information

Size
Order no.
Price

CD22-APC

  • REA340
  • CE–IVD
for 100
tests
170-078-019
-

CD22-VioBlue

  • REA340
  • CE–IVD
for 100
tests
170-078-018
-