CD19 antibodies

CD19 antibodies

Clone: REA675
REA675 recognizes the human CD19 antigen, a type I transmembrane glycoprotein of 95 kDa that belongs to the immunglobulin superfamily. CD19 is expressed on B cells throughout most stages of B cell differentiation, though its expression is down-regulated during their terminal differentiation to plasma cells. Expression of CD19 is also found in the majority of B cell–derived malignancies. CD19 is further present on follicular dendritic cells. On B cells, CD19 associates with CD21, CD81, and CD225 (Leu-13) forming a signal transduction complex.
Additional information: Clone REA675 displays negligible binding to Fc receptors.

Applications

Reagent can be used for immunophenotyping by flow cytometry. Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis.
Expression of CD19 may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia.

Alternative Names

B4, Leu-12

Technical specifications

  • Antigen: CD19
  • Clone: REA675
  • Isotype: recombinant human IgG1
  • Alternative names of antigen: B4, Leu-12
  • Distribution of antigen: B cells, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
Product options: 3

Product information

Size
Order no.
Price

CD19-PE

  • REA675
  • CE–IVD
for 100
tests
170-078-089
-

CD19-APC

  • REA675
  • CE–IVD
for 100
tests
170-078-090
-

CD19-PE-Vio770

  • REA675
  • CE–IVD
for 100
tests
170-080-017
-