CD123 antibodies

CD123 antibodies

Clone: AC145
AC145 recognizes human CD123, also known as IL-3 receptor α-chain. It is the primary low-affinity subunit of the IL-3 receptor. CD123 associates with CD131, the common β-chain of the IL-3, IL-5, and GM-CSF receptor, to form the high-affinity IL-3 receptor. The IL-3 receptor is involved in cell signaling for cell growth and differentiation. In peripheral blood, the CD123 antigen is expressed at high levels only on plasmacytoid dendritic cells and basophilic granulocytes but at low levels also on monocytes, eosinophilic granulocytes, myeloid dendritic cells, and subsets of hematopoietic progenitor cells.

Applications

Reagent can be used for immunophenotyping by flow cytometry. Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis.
Expression of CD123 may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia.

Alternative Names

IL3RA, IL3R, IL3RAY, hIL-3Ra, IL-3Rα

Technical specifications

  • Antigen: CD123
  • Clone: AC145
  • Isotype: mouse IgG2aκ
  • Alternative names of antigen: IL3RA, IL3R, IL3RAY, hIL-3Ra, IL-3Rα
  • Molecular mass of antigen [kDa]: 41
  • Distribution of antigen: B cells, basophils, bone marrow, brain, endothelial cells, eosinophils, granulocytes, leukemia cells, macrophages, mast cells, megakaryocytes, monocytes, myeloid cells, placenta, red blood cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
Product options: 1

Product information

Size
Order no.
Price

CD123-PE

  • AC145
  • CE–IVD
for 100
tests
170-078-039
-