CD10 antibodies

CD10 antibodies

Clone: 97C5
97C5 recognizes human CD10, the human common acute lymphoblastic leukemia antigen (CALLA). CD10 is a 100 kDa cell surface molecule identical to human membrane-associated neutral endopeptidase (NEP) and also known as neprilysin or enkephalinase. Human CD10 is expressed on a wide variety of normal and neoplastic cell types from different tissues including neural and hematopoietic cells. It is expressed on pre– and pro–B cells and is involved in B cell development and differentiation. The antigen is also present on mature neutrophils, T cell precursors, and some T cell leukemias/lymphomas. Furthermore, CD10 is expressed on neoplastic cells of several B lymphoid leukemias/lymphomas.

Applications

Reagent can be used for immunophenotyping by flow cytometry. Abnormal numbers of cells expressing this antigen or aberrant expression levels of the antigen can be expected in some disease states. It is important to understand the normal expression pattern for this antigen and its relationship to expression of other relevant antigens in order to perform appropriate analysis.
Expression of CD10 may be used as aid to diagnostic in the characterization of samples from individuals suspected with hematologic neoplasia.

Alternative Names

CALLA, gp100, NEP

Technical specifications

  • Antigen: CD10
  • Clone: 97C5
  • Isotype: mouse IgG1
  • Alternative names of antigen: CALLA, gp100, NEP
  • Molecular mass of antigen [kDa]: 85
  • Distribution of antigen: B cells, bone marrow, brain, epithelial cells, fibroblasts, granulocytes, gut, kidney, leukemia cells, ES and iPS cells, smooth muscle, stromal cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Certificates of Analysis (CoA)

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