Exosome research solutions for infectious diseases

Exosomes are extracellular vesicles (EVs) involved in intercellular communication and known to reflect the physio-pathological condition of the parent cell. They are considered possible players in viral transmission and immune response modulation. Furthermore, their potential role as diagnostic biomarkers and delivery vehicles for drugs and vaccines is currently under investigation. 

Learn more about our exosome research solutions:

Exosome isolation  
with Exosome Isolation Kits, human 

Isolate highly pure exosomes without the need for ultracentrifugation.

• Targeted immunomagnetic isolation based on
CD9, CD63, CD81, or all three makers combined 
• Isolation from cell culture supernatant or body fluids
• Input sample volumes starting from 0.5 mL 
• Fast (<2 h) protocol

Exosome Isolation Kit Pan

MACSPlex Exosome Kit

Exosome analysis 
with MACSPlex Exosome Kit, human 

Perform a comprehensive semi-quantitative analysis of exosome markers (e.g. immunology epitopes).

• Bead-based flow cytometry assay  
• Analysis of 37 surface markers in parallel
• No pre-enrichment necessary 
• Fast (<2 h) and easy protocol  

Our kits make a difference

Plasma exosomes isolated with our Exosome Isolation Kits* and analyzed with the MACSPlex Exosome Kit reveal strong signals in comparison to exosomes isolated by ultracentrifugation.

Surface marker profiles of extracellular vesicles isolated from plasma by ultracentrifugation or immunomagnetic isolation using the Exosome Isolation Kits CD9, CD63, or CD81.
EVs from 2 mL of plasma were isolated using one of the kits or by ultracentrifugation. Amounts were adjusted to a plasma volume of 2 mL, and exosomes were analyzed using the MACSPlex Exosome Kit. Data indicate median APC signal intensities of isolated EVs. REA and mIgG1 indicate isotype control beads.

*Please note: It is not possible to combine the Exosome Isolation Kit Pan, human with the MACSPlex Exosome Kit, human.

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Discover how our research solutions successfully support scientists to investigate exosomes

Robust EV profiling in various sample types with the MACSPlex Exosome Kit. Goergens, A. et al. (2019)
Application note

Robust EV profiling in various sample types with the MACSPlex Exosome Kit
The combination of Exosome Isolation Kits and the MACSPlex Exosome Kit allows the phenotyping of EVs released during physical exercise. Brahmer et al. (2019)
Application note

Combination of Exosome Isolation Kits and MACSPlex Exosome Kit allows phenotyping of EVs released during physical exercise
Isolation of highly pure urinary extracellular vesicle fractions suitable for downstream RNA cargo sequencing. (Mussack et al., 2020)
Application note

Isolation of highly pure urinary extracellular vesicles suitable for downstream RNA cargo sequencing 

Check out this scientific publication to learn how the MACSPlex Exosome Kit, human can help you to distinguish exosomes which originated from different immune cells: 

  • Koliha N. et al. (2016) A novel multiplex bead-based platform highlights the diversity of extracellular vesicles. (PMID: 26901056)

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