CD230 (PrP) antibodies, human

CD230 (PrP) antibodies, human

Clone: REA203 | Dilution: 1:11
Clone REA203 recognizes CD230, commonly known as the prion protein (PrP). The normal cellular PrP (PrP
c
) is a ubiquitously expressed glycosylphosphatidyl-inositol (GPI) anchored protein. Though the main function of PrP
c
remains unknown, it has been suggested that PrP
c
may play a role in copper regulation, antioxidant activity, intracellular signaling. PrP
sc
is the conformational isoform of PrP
c
with similar primary sequence but different tertiary structure and is associated with neurodegenerative diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy, and scrapie in sheeps. PrP
sc
is suggested to derive from PrP
c
in a posttranslational process which involves PrP
c
-PrP
sc
molecular interactions.
Additional information: Clone REA203 displays negligible binding to Fc receptors.

Alternative names

PRNP, ASCR, CJD, GSS, KURU, PRIP, PrP, p27-30

Technical specifications

  • Antigen: CD230 (PrP)
  • Clone: REA203
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: PRNP, ASCR, CJD, GSS, KURU, PRIP, PrP, p27-30
  • Distribution of antigen: brain
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Maas, E. et al. (2007) Scrapie infection of Prion protein-deficient cell line upon ectopic expression of mutant Prion proteins. J. Biol. Chem. 282: 18702-18710
    2. Basu, S. et al. (2007) Modulation of proteinase K-resistant Prion protein in cells and infectious brain homogenate by redox iron: Implications for prion replication and disease pathogenesis. Mol. Cell. Biol. 18: 3302-3312
Product options: 8
130-101-305

CD230 (PrP)-PE, human

for 30
tests
(1)
SGD 235.00
130-101-304

CD230 (PrP)-PE, human

for 100
tests
(1)
SGD 580.00
130-101-284

CD230 (PrP)-APC, human

for 30
tests
(1)
SGD 235.00
130-101-283

CD230 (PrP)-APC, human

for 100
tests
(1)
SGD 580.00
130-101-308

CD230 (PrP)-PE-Vio770, human

for 30
tests
(1)
SGD 265.00
130-101-286

CD230 (PrP)-PE-Vio770, human

for 100
tests
(1)
SGD 630.00
130-105-096

CD230 (PrP)-Biotin, human

for 30
tests
(1)
SGD 195.00
130-105-066

CD230 (PrP)-Biotin, human

for 100
tests
(1)
SGD 485.00