CD212 antibodies, human

CD212 antibodies, human

Clone: REA242 | Dilution: 1:11
Clone REA242 recognizes CD212, which is also known as interleukin 12 (IL-12) receptor β1 subunit. CD212 is a single-pass type I membrane protein and belongs to the type 2 subfamily of cytokines receptors. It forms a heterodimeric complex with IL-12β2 to form IL-12 receptor and with IL-23R to form IL-23 receptor. IL-12 and IL-23 are heterodimeric cytokines produced mainly by antigen-presenting cells (APCs), such as macrophages, dendritic cells, B cells, and activated T and NK cells.
Additional information: Clone REA242 displays negligible binding to Fc receptors.

Alternative names

IL12RB1, IL-12R-BETA1, IL12RB, IMD30,
IL-12 receptor β1
subunit

Technical specifications

  • Antigen: CD212
  • Clone: REA242
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: IL12RB1, IL-12R-BETA1, IL12RB, IMD30,
    IL-12 receptor β1
    subunit
  • Entrez Gene ID: 3594
  • Molecular mass of antigen [kDa]: 70
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: B cells, macrophages, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Chang, J. T. et al. (2000) Role of costimulation in the induction of the IL-12/IL-12 receptor pathway and the development of autoimmunity. J. Immunol. 164: 100-106
    2. Nagayama, H. et al. (2000) IL-12 responsiveness and expression of IL-12 receptor in human peripheral blood monocyte-derived dendritic cells. J. Immunol. 165: 59-66
    3. Presky, D. H. et al. (1998) Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex. J. Immunol. 160: 2174-2179
Product options: 6
130-101-541

CD212-PE, human

for 30
tests
(1)
SGD 250.00
130-101-480

CD212-PE, human

for 100
tests
(1)
SGD 590.00
130-101-539

CD212-APC, human

for 30
tests
(1)
SGD 250.00
130-101-495

CD212-APC, human

for 100
tests
(1)
SGD 590.00
130-101-481

CD212-Biotin, human

for 30
tests
(1)
SGD 210.00
130-101-535

CD212-Biotin, human

for 100
tests
(1)
SGD 500.00