Anti-MICA/MICB antibodies, human

Anti-MICA/MICB antibodies, human

Clone: REA1076 | Dilution: 1:50
Clone REA1076 recognizes MICA and MICB, which are transmembrane glycoproteins related to major histocompatibility complex (MHC) class I molecules. In contrast to other MHC class I proteins, MICA and MICB have no association with β2-microglobulin and do not bind peptides. They are ligands for NKG2D, which is expressed on NK cells and many T cells. MICA and MICB are expressed on endothelial cells and fibroblasts and are stress-induced in epithelial cells.
Additional information: Clone REA1076 displays negligible binding to Fc receptors.

Alternative names

MICB, PERB11.2, MICA, PERB11.1

Technical specifications

  • Antigen: MICA/MICB
  • Clone: REA1076
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: MICB, PERB11.2, MICA, PERB11.1
  • Entrez Gene ID: 100507436, 4277
  • Molecular mass of antigen [kDa]: 41
  • Distribution of antigen: endothelial cells, epithelial cells, fibroblasts, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Houchins, J. P. et al. (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J. Exp. Med. 173(4): 1017-1020
    2. Bauer, S. et al. (1999) Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285: 727-729
    3. Li, P. et al. (1999) Crystal structure of the MHC class I homolog MIC-A, a γδ T cell ligand. Immunity 10: 577-584
Product options: 14
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