Anti-SSEA-4 MicroBeads, human

Anti-SSEA-4 MicroBeads, human

Anti-SSEA-4 MicroBeads have been developed for the positive selection or depletion of SSEA-4
+
pluripotent or tissue stem cells.

Background information

Stage-specific embryonic antigen 4 (SSEA-4) is a glycolipid epitope that is found on undifferentiated human embryonic stem (ES) cells
1
, induced pluripotent (iPS) cells
2
embryonal carcinoma (EC) cells
3
, and embryonic germ (EG)
4
cells and a variety of somatic stem cells, such as dental pulp stem cells, umbilical cord blood-derived very small embryonic like stem cells (VSELs)
5
and mesenchymal stromal cells
6
.

Columns

For positive selection: LS or autoMACS
®
Columns. For depletion: LD or autoMACS Columns.
  • Selected references

    1. Thomson, J. A. et al. (1998) Embryonic stem cell lines derived from human blastocysts. Science 282: 1145-1147
    2. Valamehr, B. et al. (2012) A novel platform to enable the high-throughput derivation and characterization of feeder-free human iPSCs. Sci. Rep. 2: 213
    3. Kannagi, R. et al. (1983) Stage-specific embryonic antigens (SSEA-3 and -4) are epitopes of a unique globo-series ganglioside EMBO J. 2(12): 2355-2361
    4. Shamblott, M. J. et al. (1999) Proc. Natl. Acad. Sci. U.S.A. 95: 13726-13731
    5. Bhartiya, D. et al. (2012) Very small embryonic-like stem cells with maximum regenerative potential get discarded during cord blood banking and bone marrow processing for autologous stem cell therapy. Stem Cells Dev. 21: 1-6
    6. D'Ippolito, G. et al. (2006) Sustained stromal stem cell self-renewal and osteoblastic differentiation during aging. Rejuvenation Res. 9: 10-19
Product options: 1
for 1×
10
9
total cells
SGD 981.00

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