CD209b (SIGN-R1) antibodies, mouse

CD209b (SIGN-R1) antibodies, mouse

Clone: REA125 | Dilution: 1:10
Clone REA125 recognizes the mouse CD209b antigen, a single-pass type II membrane protein also known as DC-SIGN-related protein 1 (SIGN-R1). CD209b was identified by examination of the mouse genome in search of the complete set of proteins related to the human glycan binding receptor CD209 (DC-SIGN). Unlike the human CD209, mouse CD209b is not expressed on dendritic cells (DCs) but is on splenic marginal zone, lymph node, and peritoneal macrophages. Its high affinity for murine ICAM-2, and its localization at sites that are in close contact with blood, suggest a role for CD209b in lymphocyte migration from the blood into tissues. Moreover, marginal zone macrophages in the spleen efficiently capture blood-borne antigens
in vivo
through CD209b. CD209b has also been shown to interact with the TLR signaling system, with CD209b associating with the TLR4-MD2 complex to enhance signal transduction in response to LPS in Gram-negative bacteria
in vitro
Additional information: Clone REA125 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: CD209b (SIGN-R1)
  • Clone: REA125
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: DC-SIGNR1, OtB7, SIGNR1, mSIGNR1
  • Entrez Gene ID: 69165
  • Molecular mass of antigen [kDa]: 37
  • Distribution of antigen: macrophages, spleen, lymphocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Saunders, S. P. et al. (2001) C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide. J. Immunol. 184(5): 2627-2637
    2. Geijtenbeek, T. B. et al. (2002)
      Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens
      in vivo
      Blood 100(8): 2908-2916
    3. Park, C. G. et al. (2001) Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. Int. Immunol. 13(10): 1283-1290
Product options: 6
9 µg in 300 µL (1)
SEK 675,00 
30 µg in 1 mL (1)
SEK 1 070,00 
9 µg in 300 µL (1)
SEK 715,00 
30 µg in 1 mL (1)
SEK 1 070,00 
9 µg in 300 µL (1)
SEK 215,00 
30 µg in 1 mL (1)
SEK 440,00 

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