Anti-RORγ (t) antibodies, human and mouse

Anti-RORγ (t) antibodies, human and mouse

Clone: REA278 | Dilution: 1:11
Clone REA278 recognizes the retinoid-related orphan receptor-γ (RORγ) antigen and the RORγ (t) isoform, which are ligand-dependent transcription factors that play roles in multiple physiological processes. RORγ is expressed with highest levels in several tissues like muscle, kidney, and liver, whereas RORγ (t) is expressed almost exclusively in immature CD4
double-positive thymocytes. RORγ is the possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivator recruitment. It is essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. RORγ (t) negatively regulates expression of Fas ligand and IL-2 production in T cells. It also binds to the TEA promoter and may be part of the pre-TCR activation cascade leading to the maturation of α/β T cells and may participate in the regulation of DNA accessibility in the TCR-Jα locus.
Additional information: Clone REA278 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: RORγ (t)
  • Clone: REA278
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: RORC, NR1F3, RORG, RZR-GAMMA, RZRG, TOR, RORgamma, Thor
  • Entrez Gene ID: 6097
  • Molecular mass of antigen [kDa]: 58 (56)
  • Distribution of antigen: thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: Vio515, PE
  • Selected references

    1. Moretti, S. et al. (2017) A mast cell-ILC2-Tʜ9 pathway promotes lung inflammation in cystic fibrosis. Nat Commun 8: 14017
    2. He, Y. W. et al. (1998) RORγ t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity 9(6): 797-806
    3. Villey, I. et al. (1999) RORγT, a thymus-specific isoform of the orphan nuclear receptor RORγ / TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoter. Eur. J. Immunol. 29(12): 4072-4080
    4. Jin, L. et al. (2010) Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORγ. Mol Endocrinol. 24(5): 923-929
Product options: 2
for 30
SEK 1 200,00 
for 100
SEK 2 895,00 

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