Anti-Btk antibodies, human

Anti-Btk antibodies, human

Clone: REA367 | Dilution: 1:11
Clone REA367 recognizes the human bruton tyrosine kinase (Btk) antigen, a non-receptor tyrosine kinase belonging to the Tec family of kinases. Btk is critical for B cell–development, –differentiation, and –signaling. Moreover, Btk expression is assumed to be a prerequisite for B cell–proliferation and –survival. Consequently, Btk-deficient B lymphocytes fail to reach the mature state and are presumably doomed to premature death. Btk is reported to be associated with human disease. Thus, individuals harboring loss-of-function mutations in the gene encoding Btk virtually lack circulating B lymphocytes, are unable to generate immunoglobulins of all classes, and therefore cannot mount humoral immune responses. This primary immunodeficiency is named X-linked agammaglobulinemia.
Additional information: Clone REA367 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: Btk
  • Clone: REA367
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA
  • Entrez Gene ID: 695
  • Molecular mass of antigen [kDa]: 76
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
  • Selected references

    1. Vetrie, D. et al. (1993) The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature 361(6409): 226-233
    2. Tsukada, S. et al. (1993) Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell 72(2): 279-290
    3. Mohamed, A. J. et al. (2009) Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol. Rev. 228(1): 58-73
Product options: 2
for 30
SEK 1 130,00 
for 100
SEK 2 770,00 

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