Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
MUC1, Mucin-1, EMA, PUM, PEM, CA 15-3, Episialin, H23AG

Specifications for CD227 (Muc-1) Antibody, anti-human, REAfinity™


Clone REA448 recognizes the human CD227 antigen, a single-pass type I membrane protein which is also known as mucin-1 (MUC-1), episialin, or epithelial membrane antigen (EMA). CD227 is a heterodimeric epithelial cell glycoprotein that is normally expressed at low levels on the apical surface of epithelial cells and on some hematopoietic cell lineages including subsets of T cells, B cells, monocytes, and dendritic cells. In most adenocarcinomas and in other inflammatory diseases of epithelial tissues, CD227 is overexpressed and loses the polarity of its expression. On normal epithelia, CD227 is extensively O-glycosylated with long branched glycans, whereas on tumor cells they are markedly hypoglycosylated with simpler and shorter glycan chains. Elevated levels of CD227 on the tumor have been associated with invasiveness and poor prognosis in colon, pancreas, breast, and bladder cancer. CD227 regulates the metabolite flux at multiple levels. Serving as a transcriptional co-activator, CD227 directly regulates expression of metabolic genes. By regulating receptor tyrosine kinase signaling, CD227 facilitates production of biosynthetic intermediates required for cell growth. CD227 also modulates the activity/stability of enzymes and transcription factors that directly regulate metabolic functions.
Additional information: Clone REA448 displays negligible binding to Fc receptors.

Alternative names

MUC1, Mucin-1, EMA, PUM, PEM, CA 15-3, Episialin, H23AG

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
AntigenCD227 (Muc-1)
Alternative names of antigenMUC1, Mucin-1, EMA, PUM, PEM, CA 15-3, Episialin, H23AG
Molecular mass of antigen [kDa]120(sum of molecular weights of subunits)
Distribution of antigenepithelial cells, T cells, B cells, monocytes, dendritic cells
Entrez Gene ID4582
RRIDAB_2751978, AB_2656429, AB_2656430, AB_2656431, AB_2656432, AB_2656433, AB_2904847, AB_2904846, AB_2921964, AB_2921947, AB_2752008

Resources for CD227 (Muc-1) Antibody, anti-human, REAfinity™


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References for CD227 (Muc-1) Antibody, anti-human, REAfinity™


  1. Stroopinsky, D. et al. (2013) MUC1 is a potential target for the treatment of acute myeloid leukemia stem cells. Cancer Res. 73(17): 5569-5579
  2. Lan, M. S. et al. (1990) Cloning and sequencing of a human pancreatic tumor mucin cDNA. J. Biol. Chem. 265(25): 15294-15299
  3. Andrulis, M. et al. (2014) Expression of Mucin-1 in multiple myeloma and its precursors: correlation with glycosylation and subcellular localization. Histopathology 64(6): 799-806

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