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Ultrahigh-content imaging helps to identify CAR target candidates for the fight against pancreatic adenocarcinoma

Making use of the innovative MICS (MACSima™ Imaging Cyclic Staining) technology, Daniel Schäfer has overcome a major scientific obstacle which so far has impeded the development of effective cellular immunotherapy of pancreatic ductal adenocarcinoma – the lack of suitable tumor-specific antigens. His research led to the identification of four target candidates among 371 antigens. This in turn resulted in the generation of 32 CARs whose potential for therapeutic approaches has been evaluated. Daniel Schäfer will explain how he identified the potential targets, how CAR T cell activity was evaluated in vitro and, based on that, how promising constructs were used to assess their activity in vivo. Efficacies in pre-clinical studies ranged from stabilized disease to complete tumor eradication.