Clone:
REA610
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
MHC class II IAk, Aßk, A beta K, Aalpha, H-2Aa, H2Aa, I-Aalpha, IAalpha

Specifications for MHC Class II (I-Ak) Antibody, anti-mouse, REAfinity™

Overview

Clone REA610 recognizes the β chain of the mouse MHC class II alloantigen I-Ak of H-2k bearing mouse strains. It also cross-reacts with the H-2f, H-2r, and H-2s haplotypes, but reactivity to other haplotypes (i.e., b, d, p, and q) has not been observed. It also cross-reacts with splenocytes from nonobese diabetic (NOD) mice, and with lymph node cells of BN, DA, WRA, and WRC rats. MHC class II is expressed on antigen-presenting cells, such as dendritic cells, monocytes, macrophages, B cells in lymphoid and non-lymphoid tissue, thymic epithelial cells, and on subsets of hematopoietic progenitor cells in the bone marrow.
Additional information: Clone REA610 displays negligible binding to Fc receptors.

Alternative names

MHC class II IAk, Aßk, A beta K, Aalpha, H-2Aa, H2Aa, I-Aalpha, IAalpha

Detailed product information

Technical specifications

CloneREA610
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenMHC Class II (I-Ak)
Alternative names of antigenMHC class II IAk, Aßk, A beta K, Aalpha, H-2Aa, H2Aa, I-Aalpha, IAalpha
Molecular mass of antigen [kDa]26
Distribution of antigenB cells, dendritic cells, macrophages, monocytes, thymic epithelial cells, hematopoietic stem and progenitor cells
Entrez Gene ID14960
RRIDAB_2652871, AB_2652872, AB_2652873, AB_2652874, AB_2652875, AB_2652876, AB_2652877, AB_2652878, AB_2652879, AB_2652880, AB_2652881, AB_2652870

Resources for MHC Class II (I-Ak) Antibody, anti-mouse, REAfinity™

Certificates

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References for MHC Class II (I-Ak) Antibody, anti-mouse, REAfinity™

Publications

  1. Bhattacharya, A. et al. (1981) A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication. J. Immunol. 127(6): 2488-2495
  2. Nelson, C. A. et al. (1996) A negatively charged anchor residue promotes high affinity binding to the MHC class II molecule I-Ak. J. Immunol. 157(2): 755-762
  3. Ting, J. P. et al. (2002) Genetic control of MHC class II expression. Cell 109: 21-33

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