REAlease® CD27 Complexes, human

CD27 Complexes
, human

Clone: REAL173 | Dilution: 1:50
Clone REAL173 is an antibody fragment derived from the full CD27 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL173 recognizes the human CD27 antigen, a single-pass type I membrane protein, also known as tumor necrosis factor receptor superfamily member 7 (TNFRSF7). CD27 is a member of the nerve growth factor receptor family and is exclusively expressed on cells of the lymphoid lineage, mostly in an activation-specific manner, and all enhance T cell receptor (TCR)–induced T cell expansion. CD27 and its ligand, CD70, have been defined at the protein, cDNA, and genomic level in both human and mouse. It is found on NK, T, and B cell populations. The majority of CD4
and CD8
naive peripheral T cells express CD27 and expression is up-regulated upon TCR stimulation. Loss of CD27 expression is irreversible and seems to represent terminal effector T cell differentiation. In humans, naive B cells lack CD27 but antigen receptor stimulation induces expression. CD27
B cells display all the functional and phenotypic characteristics of memory cells.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

S152, TNFRSF7, Tp55, T14, S152. LPFS2

Technical specifications

  • Antigen: CD27
  • Clone: REAL173
  • Isotype control: REAL Control
  • Alternative names of antigen: S152, TNFRSF7, Tp55, T14, S152. LPFS2
  • Distribution of antigen: NK cells, T cells, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
  • Selected references

    1. Camerini, D. et al. (1991) The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. J. Immunol. 147(9): 3165-3169
    2. Gravestein, L. A. et al. (1993) Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family. Eur. J. Immunol. 23(4): 943-950
    3. Prasad, K. V. et al. (1997) CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. Proc. Natl. Acad. Sci. U.S.A. 94(12): 6346-6351
Product options: 3
for 30
EUR  134,00
for 100
EUR  330,00
for 100
EUR  381,00

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