REAlease® CD101 Complexes, mouse

CD101 Complexes
, mouse

Clone: REAL172 | Dilution: 1:50
Clone REAL172 is an antibody fragment derived from the full CD101 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL172 recognizes the mouse CD101 antigen, a type I transmembrane glycoprotein also known as Immunoglobulin superfamily member 2 (IgSF2) or V7. CD101 is expressed on monocytes, granulocytes, dendritic cells (DCs), and activated T cells. In humans CD101 inhibits the proliferative response of T cells to allogeneic cells or immobilized anti-CD3 antibody, suggesting that engagement of CD101 can antagonize TCR/CD3-mediated lymphocyte activation. Moreover, human peripheral CD8
T cells that express CD101 and CD103 display suppressive function after activation with intraepithelial cells or placental trophoblasts. In addition to its role on T cells, triggering CD101 on human cutaneous DC inhibits T cell proliferation via interleukin 10 (IL-10) production, suggesting that the CD101 molecule may be involved in tolerance induction. Studies in mice showed that cell surface expression of CD101 is highly correlated with functional suppressor activity within CD4
regulatory T cells both
in vitro
in vivo
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

EWI-101, Gm1016, Gm734, IGSF2

Technical specifications

  • Antigen: CD101
  • Clone: REAL172
  • Isotype control: REAL Control
  • Alternative names of antigen: EWI-101, Gm1016, Gm734, IGSF2
  • Distribution of antigen: monocytes, granulocytes, dendritic cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE
  • Selected references

    1. Penha-Gonçalves, C. et al. (2003) Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. Diabetes 52(6): 1551-1556
    2. Fernandez, I. et al. (2007)
      CD101 surface expression discriminates potency among murine FoxP3
      regulatory T cells.
      J. Immunol. 179(5): 2808-2814
    3. Mohammed, J. P. et al. (2011)
      Identification of CD101 as a susceptibility gene for
      Novosphingobium aromaticivorans
      -induced liver autoimmunity.
      J. Immunol. 187(1): 337-349
Product options: 4
30 µg in 200 µL (1)
EUR  113,00
30 µg in 200 µL (1)
EUR  113,00
for 100
EUR  165,00
for 100
EUR  165,00

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