CD95 (FAS) antibodies, human

Clone: REA738
Clone REA738 recognizes the human CD95 antigen, also known as Fas and Apo-1, which is a member of the tumor necrosis factor receptor superfamily (TNFR) and is found on the surface of many normal and neoplastically transformed cells. Its ligand, CD95L (FasL/Apo-1L), is able to induce apoptosis in CD95-expressing cells upon binding. CD95 and CD95L are up-regulated on lymphocytes upon activation and are known to play a key role in the regulation of an inflammatory response: Juxtocrine “fratricide” of neighbouring lymphocytes via mutual CD95 and CD95L expression helps to terminate immune responses, while apoptosis of pro-inflammatory cells via CD95 helps maintain immune privilege in sites such as the eye, where CD95L is found to be expressed in the retina and cornea. Cross-linking of CD95 receptors by DX2 monoclonal antibody has been described to induce apoptosis in certain target cells.
Additional information: Clone REA738 displays negligible binding to Fc receptors.

Alternative names

FAS, ALPS1A, APO-1, Apt1, FAS1, FASTM, Tnfrsf6

Technical specifications

  • Antigen: CD95 (FAS)
  • Clone: REA738
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FAS, ALPS1A, APO-1, Apt1, FAS1, FASTM, Tnfrsf6
  • Entrez Gene ID: 355
  • Molecular mass of antigen [kDa]: 35
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    rhesus monkey (
    Macaca mulatta
    african green monkey (
    Chlorocebus aethiops
    , baboon, capuchin monkey,
    chimpanzee (
    Pan troglodytes
    common marmoset (
    Callithrix jacchus
    cotton-top tamarin (
    Saguinus oedipus
    pigtail monkey (
    Macaca nemestrina
    sooty mangabey (
    Cercocebus atys
  • Distribution of antigen: lymphocytes
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
Product options: 1
100 µg in 100 µL
EUR  164,00