CD84 antibodies, human

CD84 antibodies, human

Clone: MZ18-21F6 | Dilution: 1:11
Human CD84 is a 65–80 kDa single-chain surface glycoprotein and member of the CD2 subset of the immunoglobulin (Ig) superfamily. CD84 is expressed on granulocytes, monocytes, macrophages, B cells, platelets, antigen-presenting cells, and subsets of T cells including thymocytes and mature T cells. Homophilic ligation of CD84 or ligation with CD84 antibodies has been shown to lead to enhanced proliferation of T cells as well as IFN-γ secretion. CD84 thus serves as a co-stimulatory molecule. CD84 gene expression has also been detected in lung and kidney tissue as well as on hematopoietic progenitor cells in bone marrow.

Alternative names

Ly9b, SLAMF5, hCD84, mCD84, GR6

Technical specifications

  • Antigen: CD84
  • Clone: MZ18-21F6
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: Ly9b, SLAMF5, hCD84, mCD84, GR6
  • Entrez Gene ID: 8832
  • Molecular mass of antigen [kDa]: 36
  • Distribution of antigen: B cells, dendritic cells, granulocytes, macrophages, monocytes, NK cells, platelets, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin, FITC
  • Selected references

    1. Martin, M. et al. (2001) CD84 functions as a homophilic adhesion molecule and enhances IFN-γ secretion: adhesion is mediated by Ig-like domain 1. J. Immunol. 167: 3668-3676
    2. Romero, X. et al. (2004) Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). Tissue Antigens 64(2): 132-144
    3. de la Fuente, M. A. et al. (1997) CD84 leukocyte antigen is a new member of the Ig superfamily. Blood 90: 2398-2405
    4. Zaiss, M. et al. (2003) CD84 expression on human hematopoietic progenitor cells. Exp. Hematol. 31: 798-805
    5. Tangye, S. G. et al. (2003) Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. J. Immunol. 171: 2485-2495
Product options: 4
130-093-278

CD84-FITC, human

for 100
tests
(1)
EUR  220,00
130-093-277

CD84-PE, human

for 100
tests
(1)
EUR  265,00
130-093-276

CD84-APC, human

for 100
tests
(1)
EUR  265,00
for 100
tests
(1)
EUR  220,00

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