CD81 antibodies, human

CD81 antibodies, human

Clone: REA513 | Dilution: 1:50
Clone REA513 recognizes the human CD81 antigen, a multi-pass membrane protein also known as TAPA-1. It is a member of the tetraspanin family including, for example, CD9, CD37, CD53, CD63, CD82, and CD151. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth, and motility. The 26 kDa cell surface protein is involved in adhesion, activation, proliferation, and differentiation of B cells, T cells, and other cells. On B cells CD81 is part of a complex with CD21, CD19, and Leu13. Similarly on T cells CD81 associates with CD4 and CD8 and provides a costimulatory signal with CD3. CD81 is expressed by epithelial and endothelial cells, T and B cells, as well as natural killer (NK) cells.
Additional information: Clone REA513 displays negligible binding to Fc receptors.

Alternative names

CVID6, S5.7, TAPA1, TSPAN28

Technical specifications

  • Antigen: CD81
  • Clone: REA513
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CVID6, S5.7, TAPA1, TSPAN28
  • Entrez Gene ID: 975
  • Molecular mass of antigen [kDa]: 26
  • Cross-reactivity:
    chimpanzee (
    Pan troglodytes
    )
  • Distribution of antigen: epithelial cells, endothelial cells, T cells, B cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Levy, S. (1998) CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system. Annu. Rev. Immunol. 16: 89-109
    2. Wright, M. D. et al. (1994) The ins and outs of the transmembrane 4 superfamily. Immunol. Today 15(12): 588-594
    3. Levy, S. (1991) Structure and membrane topology of TAPA-1. J. Biol. Chem. 266(22): 14597-14602
    4. Oren, R. (1990) TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. Mol. Cell. Biol. 10(8): 4007-4015
Product options: 6
130-118-481

CD81-PE, human

for 30
tests
(1)
EUR  110,00
130-118-342

CD81-PE, human

for 100
tests
(1)
EUR  265,00
130-119-825

CD81-APC, human

for 30
tests
(1)
EUR  110,00
130-119-787

CD81-APC, human

for 100
tests
(1)
EUR  265,00
for 30
tests
(1)
EUR  90,00
for 100
tests
(1)
EUR  220,00

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