CD61 antibodies, mouse and rat

CD61 antibodies, mouse and rat

Clone: REA1192 | Dilution: 1:50
Clone REA1192 recognizes a 110 kDa integrin β chain known as CD61 or integrin β3. Owing to multiple α/β subunit combinations, integrins form an array of heterodimeric receptors, each recognising a multitude of ligands. CD61, in association with either αv (CD51) or αIIb (CD41) integrin, binds to fibrinogen, fibronectin, von Willebrand factor, prothrombin, disintegrins, and thrombospondin. Due to binding to various extracellular matrix proteins and cellular receptors, integrins play a significant role in cell adhesion and cell movement. Furthermore, a pro-apoptotic function of CD61 has been suggested using a hepatocellular carcinoma (HCC) cell line and patient tissues. Expression of CD61 is found on platelets, B cell subsets, myeloid cells, mast cells, osteoclasts, endothelium, megakaryocytes, and smooth muscle cells.
Additional information: Clone REA1192 displays negligible binding to Fc receptors.

Alternative names

ITGB3, GP3A, INGRB3, GPIIIa, Integrin beta-3, Integrin β3

Technical specifications

  • Antigen: CD61
  • Clone: REA1192
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: ITGB3, GP3A, INGRB3, GPIIIa, Integrin beta-3, Integrin β3
  • Entrez Gene ID: 16416
  • Molecular mass of antigen [kDa]: 84
  • Distribution of antigen: B cells, endothelial cells, megakaryocytes, mast cells, myeloid cells, platelets, smooth muscle, osteoclasts
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE-Vio615, PE-Vio770, VioBright 515, Biotin, PE
  • Selected references

    1. Wu, Y. et al. (2009) Proapoptotic function of integrin β3 in human hepatocellular carcinoma cells. Clin. Cancer Res. 15: 60-69
    2. Plow, E. F. et al. (2000) Ligand binding to integrins. J. Biol. Chem. 275: 21785-21788
Product options: 6
30 µg in 200 µL (1)
EUR  80,00
30 µg in 200 µL (1)
EUR  80,00
30 µg in 200 µL (1)
EUR  100,00
30 µg in 200 µL (1)
EUR  100,00
30 µg in 200 µL (1)
EUR  145,00
30 µg in 200 µL (1)
EUR  40,00

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