CD57 antibodies, human

CD57 antibodies, human

Clone: TB03 | Dilution: 1:50
Clone TB03 specifically recognizes human CD57. CD57, also known as HNK-1 or Leu-7, is an antigenic oligosaccharide moiety detected on extracellular proteins of certain cell types. In blood, CD57 is found on 15–20% of mononuclear cells, including subsets of natural killer (NK) and T cells, though not on erythrocytes, monocytes, granulocytes, or platelets. Also, CD57 expression can be found on a variety of neural cell types.
CD57 has been shown to be expressed on late stage effector CD8
+
T cells. The frequency of CD57
+
T lymphocytes is raised in a variety of diseases. CD57 expression is also increased on chronically activated CD8
+
T cells in persistent viral infections, such as HIV.

Alternative names

B3GAT1, GLCATP, GLCUATP, HNK-1, Leu-7, NK-1

Technical specifications

  • Antigen: CD57
  • Clone: TB03
  • Isotype: mouse IgMκ
  • Isotype control: Mouse IgM – isotype control antibodies
  • Alternative names of antigen: B3GAT1, GLCATP, GLCUATP, HNK-1, Leu-7, NK-1
  • Distribution of antigen: B cells, brain, CNS cells, NK cells, ES and iPS cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, APC-Vio770, FITC, PE-Vio615, VioBlue
  • Selected references

    1. Palmer, B. E. et al. (2005)
      Functional and phenotypic characterization of CD57
      +
      CD4
      +
      T cells and their association with HIV-1-induced T cell dysfunction.
      J. Immunol. 175: 8415-8423
    2. Brenchley, J. M. et al. (2003)
      Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8
      +
      T cells.
      Blood 101: 2711-2720
    3. Mechtersheimer, G. et al. (1991) Expression of the natural killer cell-associated antigens CD56 and CD57 in human neural and striated muscle cells and in their tumors. Cancer Res. 51: 1300-1307
    4. Dupuy d'Angeac, A. et al. (1993)
      Increased percentage of CD3
      +
      , CD57
      +
      lymphocytes in patients with rheumatoid arthritis. Correlation with duration of disease.
      Arthritis Rheum. 36: 608-612
    5. Ong, E. et al. (2002)
      Biosynthesis of HNK-1 glycans on O-linked oligosaccharides attached to the neural cell adhesion molecule (NCAM): the requirement for core 2 β1,6-
      N
      -acetylglucosaminyltransferase and the muscle-specific domain in NCAM.
      J. Biol. Chem. 277: 18182-18190
Product options: 10
130-118-665

CD57-APC, human

for 30
tests
(1)
EUR  110,00
130-118-537

CD57-APC, human

for 100
tests
(1)
EUR  265,00
for 30
tests
(1)
EUR  120,00
for 100
tests
(1)
EUR  290,00
130-122-979

CD57-FITC, human

for 30
tests
(1)
EUR  90,00
130-122-935

CD57-FITC, human

for 100
tests
(1)
EUR  220,00
for 30
tests
(1)
EUR  120,00
for 100
tests
(1)
EUR  290,00
for 30
tests
(1)
EUR  115,00
for 100
tests
(1)
EUR  275,00

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