CD42a antibodies, human

CD42a antibodies, human

Clone: REA209 | Dilution: 1:11
Clone REA209 recognizes CD42a, a 22 KDa transmembrane glycoprotein, which is also known as glycoprotein IX (GPIX). CD42a is a single-pass type I membrane protein with leucine rich motif containing a series of tandem repeats of a 24-amino acid sequence flanked by conserved disulfide loops, in its ligand binding domains. Expression of CD42a is found on platelets and megakaryocytes. CD42a, together with GPIb receptor complex and platelet glycoprotein V forms a complex which serves as the receptor for von Willebrand factor (VWF). The interaction of the GPIb-IX-V complex to VWF initiates initial platelet adhesion to vascular subendothelium after vascular injury, platelet activation, thrombosis, and hemostasis. Other known ligands for GPIb–IX–V include α-thrombin, clotting factors XI/XIIa, and high-molecular weight kininogen.
Additional information: Clone REA209 displays negligible binding to Fc receptors.

Alternative names

GP9, GPIX

Technical specifications

  • Antigen: CD42a
  • Clone: REA209
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: GP9, GPIX
  • Molecular mass of antigen [kDa]: 22
  • Distribution of antigen: megakaryocytes, platelets
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Shrimpton, C. N. et al. (2002) Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation. J. Exp. Med. 196: 1057
    2. Andrews, R. K. et al. (1997) Molecular mechanisms of platelet adhesion and activation. Int. J. Biochem. Cell Biol. 29(1): 91-105
    3. Andrews, R. K. et al. (2003) Glycoprotein Ib-IX-V. Int. J. Biochem. Cell Biol. 35(8): 1170-1174
Product options: 12
for 30
tests
EUR  93,00
for 100
tests
EUR  227,00
130-100-968

CD42a-PE, human

for 30
tests
EUR  113,00
130-100-966

CD42a-PE, human

for 100
tests
EUR  273,00
130-100-934

CD42a-APC, human

for 30
tests
EUR  113,00
130-100-932

CD42a-APC, human

for 100
tests
EUR  273,00
for 30
tests
(1)
EUR  124,00
for 100
tests
(1)
EUR  299,00
for 30
tests
(1)
EUR  124,00
for 100
tests
(1)
EUR  299,00
for 30
tests
(1)
EUR  93,00
for 100
tests
(1)
EUR  227,00

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