CD337 (NKp30) antibodies, human

CD337 (NKp30) antibodies, human

Clone: AF29-4D12 | Dilution: 1:50
The CD337 receptor, also known as NKp30, is a 30 kDa type I membrane glycoprotein characterized by a single V-type Ig-like domain in the extracellular portion, and is found almost exclusively on the surface of resting or activated natural killer (NK) cells. CD337 is a member of the natural cytotoxicity receptor (NCR) family which trigger cytotoxicity in NK cells. CD337 is directly involved in target cell recognition and lysis and is expressed by all resting or activated NK cells and by a small subset of T cells. Its expression density parallels that of CD336 (NKp44). It seems to be involved in killing of cells which are lysed independently from CD336 (NKp44) and CD335 (NKp46).

Alternative names

NCR3, 1C7, LY117, MALS, NKp30

Technical specifications

  • Antigen: CD337 (NKp30)
  • Clone: AF29-4D12
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: NCR3, 1C7, LY117, MALS, NKp30
  • Entrez Gene ID: 259197
  • Molecular mass of antigen [kDa]: 20
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
  • Selected references

    1. Pende, D. et al. (1999) Identification and molecular characterization of Nkp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. J. Exp. Med. 190: 1505-1516
    2. Moretta, L. and Moretta, A. (2004) Unravelling natural killer function: Triggering and inhibitory human NK receptors. EMBO J. 23: 255-259
    3. Sivori, S. et al. (2000) 2B4 functions as a co-receptor in human NK cell activation. Eur. J. Immunol. 30: 787-793
    4. Moretta, A. et al. (2001) Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19: 197-223
Product options: 2
for 30
tests
(1)
EUR  110,00
for 100
tests
(1)
EUR  265,00

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