CD3 antibodies, human

Clone: REA613 | Dilution: 1:50
Clone REA613 recognizes the human CD3 antigen, a single-pass type I membrane protein, also known as Leu4. CD3 is present on mature human T cells, thymocytes, a subset of natural killer (NK) cells, and on Purkinje cells in cerebellum. It is associated with the T cell receptor (TCR) and is responsible for its signal transduction. The CD3 antigen is a complex of five invariable chains: γ, δ, ε, ζ, and η. The epitope recognized by the antibody is located on the ε-chain of the CD3 complex.
Additional information: Clone REA613 displays negligible binding to Fc receptors.

Alternative names

CD3-epsilon, CD3e, Leu4, T-cell surface antigen T3/Leu-4 epsilon chain, T3E, IMD18, TCRE

Technical specifications

  • Antigen: CD3
  • Clone: REA613
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD3-epsilon, CD3e, Leu4, T-cell surface antigen T3/Leu-4 epsilon chain, T3E, IMD18, TCRE
  • Entrez Gene ID: 916
  • Molecular mass of antigen [kDa]: 21
  • Distribution of antigen: leukocytes, NK cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Gold, D. P. et al. (1986) Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex. Nature 321(6068): 431-434
    2. Birnbaum, M. E. et al. (2014) Molecular architecture of the αβ T cell receptor-CD3 complex. Proc. Natl. Acad. Sci. U.S.A. 111(49): 17576-17581
    3. D'Acquisto, F. et al. (2011)
      CD3
      +
      CD4
      -
      CD8
      -
      (double negative) T cells: saviours or villains of the immune response?
      Biochem. Pharmacol. 82(4): 333-340
Product options: 20
130-113-700

CD3-FITC, human

for 30
tests
(1)
EUR  72,00
130-113-138

CD3-FITC, human

for 100
tests
(1)
EUR  180,00
130-113-701

CD3-PE, human

for 30
tests
(1)
EUR  98,00
130-113-139

CD3-PE, human

for 100
tests
(1)
EUR  242,00
130-113-697

CD3-APC, human

for 30
tests
(1)
EUR  98,00
130-113-135

CD3-APC, human

for 100
tests
(1)
EUR  242,00
for 30
tests
(1)
EUR  118,00
for 100
tests
(1)
EUR  283,00
for 30
tests
(1)
EUR  118,00
for 100
tests
(1)
EUR  283,00
for 30
tests
(1)
EUR  124,00
for 100
tests
(1)
EUR  299,00
for 30
tests
(1)
EUR  124,00
for 100
tests
(1)
EUR  299,00
for 30
tests
(1)
EUR  124,00
for 100
tests
(1)
EUR  299,00
for 30
tests
(1)
EUR  124,00
for 100
tests
(1)
EUR  299,00
for 30
tests
(1)
EUR  72,00
for 100
tests
(1)
EUR  180,00

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