CD275 (B7-H2) antibodies - functional grade, mouse

CD275 (B7-H2) antibodies - functional grade, mouse

Clone: HK5.3
Clone HK5.3 recognises murine CD275, which is also known as B7-H2 and ICOSL. CD275 is a type I membrane protein and belongs to the Ig superfamily, B7 family of costimulatory molecules. Expression of CD275 is found on antigen presenting cells such as B cells, dendritic cells, and monocytes. CD275 costimulates T cells upon binding to ICOS, which is expressed on activated T cells. In mouse, CD275 binds only ICOS, whereas in humans it can interact with other T cell costimulatory molecules, CD28 and CTLA-4. To appropriately regulate the activation of immune response, the ICOS-CD275 interaction can also lead to downregulation of CD275 expression which allows prevention of hyperreaction of T cells.


The mouse CD275 pure – functional grade antibody is suited for functional assays, for example,
in vitro
in vivo
blocking of ligand binding to B7RP-1 on mouse antigen presenting cells.

Alternative names

ICOSL, B7-H2, B7RP-1, GL50, LICOS, ICOS-Lg, Ly115l, B7h, GI50, GL50-B

Technical specifications

  • Antigen: CD275 (B7-H2)
  • Clone: HK5.3
  • Isotype: rat IgG2aκ
  • Alternative names of antigen: ICOSL, B7-H2, B7RP-1, GL50, LICOS, ICOS-Lg, Ly115l, B7h, GI50, GL50-B
  • Entrez Gene ID: 50723
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, epithelial cells, monocytes, other
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. Watanabe, M. et al. (2008) Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses. J. Immunol. 180: 5222-5234
    2. Yao, S. et al. (2011) B7-H2 is a costimulatory ligand for CD28 in human. Immunity 34(5): 729-740
Product options: 1
500 µg in 0.5 mL
EUR  322,00

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