CD256 (APRIL) antibodies, human and mouse

Clone: REA347 | Dilution: 1:10
Clone REA347 recognizes the human and mouse CD256 antigen, a protein which is a member of the TNF ligand superfamily and also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13) or a proliferation-inducing ligand (APRIL). CD256 is expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues, and specifically expressed in monocytes and macrophages. Secreted CD256 consists almost entirely of a single TNF homology domain. Little or no transmembrane CD256 is expressed on the cell surface. CD256 binds with high affinity the TNFR family members B cell maturation antigen (BCMA) and transmembrane activator and CAML-interactor (TACI). It stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-κB, and induces cell death. CD256 and its receptors BCMA and TACI are involved in diseases of autoimmunity and cancer.
Additional information: Clone REA347 displays negligible binding to Fc receptors.

Alternative names

TNFSF13, A proliferation-inducing ligand (APRIL), TALL-2, TALL2, TRDL-1, UNQ383/PRO715, ZTNF2, April

Technical specifications

  • Antigen: CD256 (APRIL)
  • Clone: REA347
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: TNFSF13, A proliferation-inducing ligand (APRIL), TALL-2, TALL2, TRDL-1, UNQ383/PRO715, ZTNF2, April
  • Entrez Gene ID: 8741
  • Molecular mass of antigen [kDa]: 16
  • Distribution of antigen: monocytes, macrophages, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio770, Biotin, PE
  • Selected references

    1. Yu, G. et al. (2000) APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat. Immunol. 1(3): 252-256
    2. Hahne, M. et al. (1998) APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J. Exp. Med. 188(6): 1185-1190
    3. Vincent, F. B. et al. (2013) The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity. Cytokine Growth Factor Rev. 24(3): 203-215
Product options: 4
for 30
EUR  124,00
for 100
EUR  299,00
for 30
EUR  98,00
for 100
EUR  237,00

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