CD180 (RP105) antibodies, mouse

CD180 (RP105) antibodies, mouse

Clone: RP/14 | Dilution: 1:10
Clone RP/14 recognizes CD180, a type I transmembrane protein structurally similar to Toll like receptors (TLRs), with the conserved features of TLRs, including a leucine-rich repeat extracellular domain and regions containing conserved cysteines. However, in contrast to TLRs, CD180 lacks a typical TIR domain, containing only 6 to 11 intracytoplasmic amino acids. Antibody mediated ligation of CD180 was shown to induce B cell proliferation and protection from subsequent radiation- or dexamethasone-induced apoptosis. Expression of CD180 is found on mature B cells, monocytes, macrophages, and dendritic cells. CD180 activity is dependent on physical association with a molecule called MD-1. In B cells, CD180, together with TLR4, has been shown to induce B cell proliferation in response to LPS. However, in primary myeloid cells and
in vivo
, CD180 acts as an inhibitor of TLR4 signaling.

Alternative names

Ly78, RP105

Technical specifications

  • Antigen: CD180 (RP105)
  • Clone: RP/14
  • Isotype: rat IgG2aκ
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: Ly78, RP105
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Divanovic, S. et al. (2007) Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105. J. Leukoc. Biol. 82: 265-271
    2. Divanovic, S. et al. (2005) Inhibition of TLR-4/MD-2 signaling by RP105/MD-1. J. Endotoxin Res. 11: 363-368
Product options: 8
9 µg in 300 µL (1)
EUR  27,00
30 µg in 1 mL (1)
EUR  80,00
9 µg in 300 µL (1)
EUR  44,00
30 µg in 1 mL (1)
EUR  80,00
9 µg in 300 µL (1)
EUR  44,00
30 µg in 1 mL (1)
EUR  100,00
9 µg in 300 µL (1)
EUR  15,00
30 µg in 1 mL (1)
EUR  40,00

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