CD159c (NKG2C) antibodies, human

CD159c (NKG2C) antibodies, human

Clone: REA205 | Dilution: 1:11
Clone REA205 recognizes the CD159c antigen, a calcium-dependent (C-type) lectin which is also known as NKG2C type II integral membrane protein or KLRC2. CD159c heterodimerizes with CD94 to form a complex that recognizes HLA-E as ligand. Clone REA205 detects the human CD159c/CD94 heterodimer and does not cross-react with the human CD159a/CD94 heterodimer or with the human CD94 homodimer. CD159c is expressed primarily on natural killer (NK) cells and receptor ligation results in NK cell activation. The proportion of CD3
+
T cells expressing the CD159c/CD94 complex is elevated under pathologic conditions, such as human CMV infection, active celiac disease, paroxysmal nocturnal hemoglobinuria, Stevens-Johnson syndrome, and toxic epidermal necrolysis.
Additional information: Clone REA205 displays negligible binding to Fc receptors.

Alternative names

KLRC2, CD159c, NKG2-C, NKG2C

Technical specifications

  • Antigen: CD159c (NKG2C)
  • Clone: REA205
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: KLRC2, CD159c, NKG2-C, NKG2C
  • Entrez Gene ID: 3822
  • Molecular mass of antigen [kDa]: 26
  • Distribution of antigen: NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: Biotin, PE
  • Selected references

    1. Houchins, J. P. et al. (1997) Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C. J. Immunol. 158(8): 3603-3609
    2. Zaguia, F. et al. (2013)
      Cytotoxic NKG2C
      +
      CD4 T cells target oligodendrocytes in multiple sclerosis.
      J. Immunol. 190(6): 2510-2518
    3. Houchins, J. P. et al. (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J. Exp. Med. 173(4): 1017-1020
    4. Kruse, V. et al. (2015) Human induced pluripotent stem cells are targets for allogeneic and autologous natural killer (NK) cells and killing is partly mediated by the activating NK receptor DNAM-1. PLoS One 10(5): e0125544
    5. López-Botet, M. et al. (1997) The CD94/NKG2C-type lectin receptor complex in recognition of HLA class I molecules. Res. Immunol. 148(3): 155-159
    6. Hydes, T. et al. (2018) IL-12 and IL-15 induce the expression of CXCR6 and CD49a on peripheral natural killer cells. Immun. Inflamm. Dis. 6(1): 34-46
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