CD158b (KIR2DL2/DL3) antibodies, human

Clone: DX27 | Dilution: 1:11
Clone DX27 reacts with CD158b1 (KIR2DL2), CD158b2 (KIR2DL3), and CD158j (KIR2DS2), members of the killer immunoglobulin-like receptor (KIR) family expressed on natural killer (NK) cells and subsets of T cells.
KIRs contribute to the regulation of NK cell–mediated cytotoxicity and possess high allelic polymorphism with either 2 or 3 Ig-like extracellular domains. According to the length of their cytoplasmic tail, KIRs can be further subdivided in inhibitory KIRs (KIR2DL or KIR3DL) and activating KIRs (KIR2DS or KIR3DS). CD158b provides an inhibitory signal on NK cell lytic activity upon interaction with HLA C (e.g. alleles HLA-Cw1, HLA-Cw3, HLA-Cw7) in an antigen-independent manner.

Alternative names

KIR2DL2, KIR2DL3

Technical specifications

  • Antigen: CD158b (KIR2DL2/DL3)
  • Clone: DX27
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: KIR2DL2, KIR2DL3
  • Entrez Gene ID: 3803
  • Molecular mass of antigen [kDa]: 35-36
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PerCP, PE-Vio770, pure
  • Selected references

    1. Farag, S. S. et al. (2002) Natural killer cell receptors: new biology and insights into the graft-versus-leukaemia effect. Blood 100(6): 1935-1947
    2. Hsu, K. et al. (2002) The killer cell immunoglobin-like (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol. Rev. 190: 40-52
    3. Selvakumar, A. et al. (1997) Polymorphism and domain variability of human killer cell inhibitory receptors. Immunol. Rev. 155: 183-196
Product options: 9
for 30
tests
(1)
EUR  113,00
for 100
tests
(1)
EUR  273,00
for 30
tests
(1)
EUR  113,00
for 100
tests
(1)
EUR  273,00
for 30
tests
(1)
EUR  113,00
for 100
tests
(1)
EUR  273,00
for 30
tests
(1)
EUR  124,00
for 100
tests
(1)
EUR  299,00
100 µg in 1 mL
EUR  203,00

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