CD157 (BST-1) antibodies, human

CD157 (BST-1) antibodies, human

Clone: REA465 | Dilution: 1:50
Clone REA465 recognizes the human CD157 antigen, a glycosylphosphatidylinositol (GPI) linked protein, which is also known as bone marrow stromal antigen 1 (BST-1) or cyclic ADP-ribose hydrolase 2. CD157, a member of the CD38 gene family, is an NAD-metabolizing ectoenzyme and a signaling molecule, which synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, former a second messenger that elicits calcium release from intracellular stores. It is mainly expressed by cells of the myeloid lineage, bone marrow stroma, and vascular endothelium. CD157 is also expressed by ovarian cancer epithelium and by peritoneal mesothelial cells, where it is implicated in tumor dissemination. Further, it is endowed with receptor-like features observed in different cell types and transduces signals by interacting with transmembrane partner molecules, a strategy shared by other GPI-anchored molecules. CD157 is involved in neutrophil polarization, adhesion, and motility and controls transendothelial migration.
Additional information: Clone REA465 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: CD157 (BST-1)
  • Clone: REA465
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: BST-1
  • Entrez Gene ID: 683
  • Molecular mass of antigen [kDa]: 30
  • Distribution of antigen: endothelial cells, granulocytes, bone marrow, stromal cells, macrophages, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Kaisho, T. et al. (1994) BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. Proc. Natl. Acad. Sci. U.S.A. 91(12): 5325-5329
Product options: 2
for 30
EUR  113,00
for 100
EUR  273,00

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