CD156a (ADAM8) antibodies, human

CD156a (ADAM8) antibodies, human

Clone: REA331 | Dilution: 1:11
Clone REA331 recognizes the human CD156a antigen, a single-pass type I transmembrane protein which is also known as disintegrin or metalloproteinase domain-containing protein 8 (ADAM8). The ADAM family members are membrane-anchored proteins with wide ranging functions, including proteolytic cleavage of cell surface molecules, cell fusion, cell adhesion, and intracellular signaling. CD156a is expressed mainly in cells of the immune system, such as monocytes, neutrophils, eosinophils, dendritic cells, and B cells. As for most ADAM family members, CD156a is involved in ectodomain shedding of membrane proteins like CD23 and L-selectin and is linked to allergic inflammation and neurodegeneration.
Additional information: Clone REA331 displays negligible binding to Fc receptors.

Alternative names

ADAM8, CD156, MS2

Technical specifications

  • Antigen: CD156a (ADAM8)
  • Clone: REA331
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ADAM8, CD156, MS2
  • Entrez Gene ID: 101
  • Molecular mass of antigen [kDa]: 87
  • Distribution of antigen: eosinophils, dendritic cells, B cells, monocytes, neutrophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Koller, G. et al. (2009) ADAM8/MS2/CD156, an emerging drug target in the treatment of inflammatory and invasive pathologies Curr. Pharm. Des. 15(20): 2272-2281
    2. Yoshiyama, K. et al. (1997) CD156 (human ADAM8): expression, primary amino acid sequence, and gene location Genomics 41(1): 56-62
    3. Matsuno, O. et al. (2008) ADAM8 in allergy. Inflamm. Allergy Drug Targets 7(2): 108-112
Product options: 4
for 30
tests
(1)
EUR  115,00
for 100
tests
(1)
EUR  270,00
for 30
tests
(1)
EUR  115,00
for 100
tests
(1)
EUR  270,00

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