CD152 antibodies, mouse

CD152 antibodies, mouse

Clone: REA984 | Dilution: 1:50
Clone REA984 recognizes the mouse CD152 antigen, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4), which is a 33 kDa member of the immunoglobin superfamily and is expressed on activated T cells at a low level. CTLA-4 and CD28 have similarities concerning B7 family counter-receptors. While CD28 delivers a co-stimulary signal in T cell activation, CD152 restricts the progression of T cells to an activated state by inhibiting interleukin 2 (IL-2) secretion and cellular proliferation. A large proportion of CTLA-4 is intracellular localized. For a complete detection it may be necessary to assess intracellular staining in addition to surface expression of CD152.
Additional information: Clone REA984 displays negligible binding to Fc receptors.

Alternative names

CTLA-4, CTLA4, Ly-56

Technical specifications

  • Antigen: CD152
  • Clone: REA984
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CTLA-4, CTLA4, Ly-56
  • Entrez Gene ID: 12477
  • Molecular mass of antigen [kDa]: 21
  • Distribution of antigen: B cells, lymphocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, Biotin
  • Selected references

    1. June, C. H. et al. (1994) The B7 and CD28 receptor families. Immunol. Today 15(7): 321-331
    2. Walunas, T. L. et al. (1994) CTLA-4 can function as a negative regulator of T cell activation. Immunity 1(5): 405-413
    3. Krummel, M. F. and Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182(2): 459-465
Product options: 7
130-116-454

CD152-PE, mouse

30 µg in 200 µL (1)
EUR  80,00
130-116-390

CD152-PE, mouse

150 µg in 1 mL (1)
EUR  230,00
130-116-455

CD152-APC, mouse

30 µg in 200 µL (1)
EUR  80,00
130-116-391

CD152-APC, mouse

150 µg in 1 mL (1)
EUR  230,00
30 µg in 200 µL (1)
EUR  100,00
150 µg in 1 mL (1)
EUR  295,00
30 µg in 200 µL (1)
EUR  40,00