CD146 (LSEC) antibodies, rat

Clone: REA697 | Dilution: 1:50
Clone REA697 recognizes the rat CD146 (LSEC) antigen, also known as Gicerin, MCAM, MUC18, or MEL-CAM. CD146 is a putative cell adhesion molecule of an immunoglobulin (Ig) superfamily which shows homophilic and heterophilic binding activities with two isoforms: S-gicerin, which has small cytoplasmic domain and the same extracellular domain as l-gicerin, shows stronger cell adhesion activity. CD146 is expressed on endothelial cells and a variety of tumor cells and is involved in cell adhesion and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. In rat, neurite promotion activity of CD146 from hippocampal neurons is reported.
Additional information: Clone REA697 displays negligible binding to Fc receptors.

Alternative names

MCAM, 1-gicerin, MUC18, S-endo, s-gicerin, Endo-CAM, Mel-CAM

Technical specifications

  • Antigen: CD146 (LSEC)
  • Clone: REA697
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: MCAM, 1-gicerin, MUC18, S-endo, s-gicerin, Endo-CAM, Mel-CAM
  • Entrez Gene ID: 78967
  • Molecular mass of antigen [kDa]: 69
  • Distribution of antigen: endothelial cells, tumor cells, neurons, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Taira, E. et al. (2004) Characterization of Gicerin/MUC18/CD146 in the rat nervous system. J. Cell. Physiol. 198(3): 377-387
Product options: 6
30 µg in 200 µL (1)
EUR  82,00
150 µg in 1 mL (1)
EUR  237,00
30 µg in 200 µL (1)
EUR  82,00
150 µg in 1 mL (1)
EUR  237,00
30 µg in 200 µL (1)
EUR  41,00
150 µg in 1 mL (1)
EUR  124,00

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