CD126 (IL-6Rα) antibodies, mouse

CD126 (IL-6Rα) antibodies, mouse

Clone: D7715A7 | Dilution: 1:10
Clone D7715A7 recognizes the mouse CD126 antigen, a type I cytokine receptor also known as interleukin 6 receptor subunit alpha (IL-6Rα) or membrane glycoprotein 80 (gp80). CD126 is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. It associates with the IL-6 receptor β chain (CD130 or gp130) resulting in the formation of a functional high affinity IL-6 receptor complex. IL-6 plays essential roles in immune response, acute phase reaction, and hematopoiesis. It is an essential factor for B cell differentiation to antibody-forming cells. Deregulated expression of the IL-6 gene is involved in polyclonal plasma cell abnormalities and oncogenesis of plasma cell neoplasias. IL-6 functions as a potent growth factor for multiple myelomas, as well as plasmacytomas. Clone D7715A7 blocks IL-6/IL-6 receptor interactions.

Alternative names

IL6RA, IL-6R, IL-6R-alpha, IL-6RA, IL-6R 1

Technical specifications

  • Antigen: CD126 (IL-6Rα)
  • Clone: D7715A7
  • Isotype: rat IgG2bκ
  • Isotype control: Rat IgG2b – isotype control antibodies
  • Alternative names of antigen: IL6RA, IL-6R, IL-6R-alpha, IL-6RA, IL-6R 1
  • Entrez Gene ID: 16194
  • Molecular mass of antigen [kDa]: 49
  • Distribution of antigen: B cells, T cells, monocytes, plasma cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
  • Selected references

    1. Yadav, M. et al. (2008) Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine Profile. J. Immunol. 180(5): 2772-2776
    2. Walker, F. et al. (2008) IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice. Blood 111(8): 3978-3985
    3. Sugita, T. et al. (1990) Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis. J. Exp. Med. 171(6): 2001-2009
Product options: 6
9 µg in 300 µL (1)
EUR  31,00
30 µg in 1 mL (1)
EUR  82,00
9 µg in 300 µL (1)
EUR  45,00
30 µg in 1 mL (1)
EUR  82,00
9 µg in 300 µL (1)
EUR  70,00
30 µg in 1 mL (1)
EUR  103,00

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