CD107b antibodies, mouse

CD107b antibodies, mouse

Clone: REA1182 | Dilution: 1:50
Clone REA1182 recognizes the mouse CD107b antigen, a highly glycosylated 110 kDa single-pass type I membrane protein also known as lysosome-associated membrane protein-2 (LAMP-2) or Mac-3 antigen. It is widely located in lysosomal membranes and the plasma membrane of macrophages and some myeloid cell lines. Under certain circumstances, e.g., after platelet activation, during granulocytic differentiation and activation, in malignant carcinoma cells, and in cytotoxic T lymphocytes, it is also found at the cell surface. CD107b has been described as a receptor for the selective import and degradation of cytosolic proteins in the lysosome or chaperone-mediated autophagy.
Additional information: Clone REA1182 displays negligible binding to Fc receptors.

Alternative names

LAMP-2, Lamp2, LGP-B, Mac-3

Technical specifications

  • Antigen: CD107b
  • Clone: REA1182
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: LAMP-2, Lamp2, LGP-B, Mac-3
  • Entrez Gene ID: 16784
  • Molecular mass of antigen [kDa]: 43
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Cha, Y. et al. (1990) The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins. J. Biol. Chem. 265(9): 5008-5013
    2. Tanaka, Y. et al. (2000) Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature 406(6798): 902-906
    3. Asaoka, Y. et al. (2013) Immunohistochemistry of LAMP-2 and adipophilin for phospholipidosis in liver and kidney in ketoconazole-treated mice. Exp. Toxicol. Pathol. 65(6): 817-823
Product options: 5
30 µg in 200 µL (1)
EUR  40,00
150 µg in 1 mL (1)
EUR  120,00
130-122-104

CD107b-PE, mouse

30 µg in 200 µL (1)
EUR  80,00
130-122-097

CD107b-PE, mouse

150 µg in 1 mL (1)
EUR  230,00
30 µg in 200 µL (1)
EUR  80,00

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