Anti-TTF-1 antibodies, human and mouse

Anti-TTF-1 antibodies, human and mouse

Clone: REA1090 | Dilution: 1:50
TTF-1 (thyroid transcripton factor-1, NKX2.1) is a homeodomain-containing transcription factor. It controls cell differentiation of telencephalic cells and is essential for proper ventral forebrain development. Furthermore, it is a key factor in the morphogenesis and differentiation of the thyroid and lung. TTF-1 is detected in primary lung adenocarcinomas and small cell carcinomas and is absent in colon and breast carcinomas. Analysis of TTF-1 expression is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating from other tumors.
Additional information: Clone REA1090 displays negligible binding to Fc receptors.

Alternative names

NKX2A, TITF1, TTF1, NKX2-1, NKx2.1, Thyroid transcription factor 1

Technical specifications

  • Antigen: TTF-1
  • Clone: REA1090
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: NKX2A, TITF1, TTF1, NKX2-1, NKx2.1, Thyroid transcription factor 1
  • Entrez Gene ID: 7080, 21869
  • Molecular mass of antigen [kDa]: 39
  • Cross-reactivity: rat
  • Distribution of antigen: lung
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, APC-Vio770, Vio515
  • Selected references

    1. Tanaka, H. et al. (2007) Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1. Cancer Res. 67(13): 6007-6011
    2. Li, Y. et al. (2013) NKX2-1 activation by SMAD2 signaling after definitive endoderm differentiation in human embryonic stem cell. Stem Cells Dev. 22(9): 1433-1442
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