Anti-TCRβ antibodies, mouse

Anti-TCRβ antibodies, mouse

Clone: REA318 | Dilution: 1:50
Clone REA318 recognizes the mouse T cell receptor beta chain (TCRβ). The T cell receptor (TCR) is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a disulfide-linked membrane-anchored heterodimeric glycoprotein normally consisting of the highly variable alpha and beta chains expressed as part of a complex with the invariant CD3 chain molecules. T cells expressing this receptor are referred to as TCRα/β T cells, though a minority of T cells express an alternate receptor, formed by variable gamma and delta chains, referred as TCRγ/δ T cells. TCRβ is expressed on TCRα/β T cells and thymocytes, NK1.1
+
thymocytes and NK-T cells.
Additional information: Clone REA318 displays negligible binding to Fc receptors.

Alternative names

TCRB, TCRbeta, Tib

Technical specifications

  • Antigen: TCRβ
  • Clone: REA318
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: TCRB, TCRbeta, Tib
  • Entrez Gene ID: 21577
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC-Vio770, PerCP-Vio700
  • Selected references

    1. Robins, H.S. et al. (2009) Comprehensive assessment of T-cell receptor β-chain diversity in αβ T cells. Blood 114(19): 4099-4107
    2. Schumm, M. et al. (2013) Depletion of T-cell receptor alpha/beta and CD19 positive cells from apheresis products with the CliniMACS device. Cytotherapy 15(10): 1253-1258
    3. Okuno, Y. et al. (2013)
      CD8
      +
      CD122
      +
      regulatory T cells contain clonally expanded cells with identical CDR3 sequences of the T-cell receptor β-chain.
      Immunology 139(3): 309-317
Product options: 3
30 µg in 200 µL (1)
EUR  100,00
150 µg in 1 mL (1)
EUR  295,00
30 µg in 200 µL (1)
EUR  100,00

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