Anti-OSCAR antibodies, human

Anti-OSCAR antibodies, human

Clone: REA494 | Dilution: 1:50
Clone REA494 recognizes the human osteoclast-associated immunoglobulin-like receptor (OSCAR) antigen, a 45 kDa single-pass type I membrane protein also known as polymeric immunoglobulin receptor 3 (PIgR-3). OSCAR is a member of the leukocyte receptor complex (LRC) protein family and is an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. OSCAR expression is detected in preosteoclasts or mature osteoclasts. Osteoclasts are terminally differentiated leukocytes that erode the mineralized bone matrix. These cells originate from hematopoietic precursors and share a common progenitor with macrophages and dendritic cells. Human OSCAR is also expressed at all stages of myeloid dendritic cell maturation, on
in vitro
derived macrophages, granulocytes, and monocyte derived dendritic cells.
Additional information: Clone REA494 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: OSCAR
  • Clone: REA494
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: PIgR3, PIgR-3, hOSCAR
  • Entrez Gene ID: 126014
  • Molecular mass of antigen [kDa]: 28
  • Distribution of antigen: dendritic cells, macrophages, osteoclasts, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
  • Selected references

    1. Barrow, A. D. et al. (2011) OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J. Clin. Invest. 121(9): 3505-3516
    2. Kim, N. et al. (2002) A novel member of the leukocyte receptor complex regulates osteoclast differentiation. J. Exp. Med. 195(2): 201-209
    3. Goettsch, C. et al. (2011) The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells. Endocrinology 152(12): 4915-4926
Product options: 2
for 30
EUR  118,00
for 100
EUR  278,00

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