Anti-O4 antibodies, human, mouse, rat

Clone: O4
During oligodendrocyte development, late A2B5
oligodendrocyte progenitors start to express O4. As the cells differentiate, A2B5 expression ceases, whereas O4 expression persists. More mature cells start to synthesize galactocerebroside, MBP, PLP, MOG, and O1. In the peripheral nervous system, O4 expression is found on Schwann cells.

Technical specifications

  • Antigen: O4
  • Clone: O4
  • Isotype: mouse IgM
  • Isotype control: Mouse IgM – isotype control antibodies
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. Jungblut, M. et al. (2012) Isolation and characterization of living primary astroglial cells using the new GLAST-specific monoclonal antibody ACSA-1. Glia 60(6): 894-907
    2. G. Kantzer, C. et al. (2017) Anti-ACSA-2 defines a novel monoclonal antibody for prospective isolation of living neonatal and adult astrocytes. Glia 65(6): 990-1004
    3. Batiuk, M. Y. et al. (2017) An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody. J. Biol. Chem. 292(21): 8874-8891
    4. Zhang, S.C. (2001) Defining glial cells during CNS development. Nat. Rev. Neurosci. 2: 840-843
    5. Sommer, I. and Schachner, M. (1981) Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: an immunocytological study in the central nervous system. Dev. Biol. 83: 311-327
Product options: 1
100 µg in 1 mL
EUR  573,00

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