Anti-Integrin β5 antibodies, human

Anti-Integrin β5 antibodies, human

Clone: REA718 | Dilution: 1:50
Clone REA718 recognizes the human integrin β5 antigen, a 95 kDa glycoprotein single-pass type I membrane protein. Integrins are a family of transmembrane receptors that mediate adhesion of cells to extracellular matrices, as well as intercellular interactions. These interactions transduce signals that control complex cell functions such as proliferation, differentiation, and survival, and require the regulation of gene expression. Integrins are heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. The integrin αV/β5 heterodimer is found on many types of tissue cells, such as epithelial cells, endothelial cells, keratinocytes, and osteoblastic cells. It is a receptor for fibronectin and vitronectin and acts as a receptor for adenovirus type C.
Additional information: Clone REA718 displays negligible binding to Fc receptors.

Alternative names

integrin b5, integrin beta 5, ITGB5

Technical specifications

  • Antigen: Integrin β5
  • Clone: REA718
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: integrin b5, integrin beta 5, ITGB5
  • Entrez Gene ID: 3693
  • Molecular mass of antigen [kDa]: 86
  • Distribution of antigen: epithelial cells, endothelial cells, keratinocytes, osteoblasts
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Kim, J. P. et al. (1994) Vitronectin-driven human keratinocyte locomotion is mediated by the alpha v beta 5 integrin receptor. J. Biol. Chem. 269(43): 26926-26932
    2. Zhang, H. et al. (6) Myosin-X provides a motor-based link between integrins and the cytoskeleton. Nat. Cell Biol. 2004(6): 523-531
    3. Lyle, C. et al. (2010) Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells. J. Virol. 7(148): 1743-1745
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EUR  290,00
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EUR  90,00
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EUR  220,00

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