Anti-IL-12 (p40/p70) antibodies, mouse

Anti-IL-12 (p40/p70) antibodies, mouse

Clone: REA136 | Dilution: 1:10
Clone REA136 recognizes the 40 kDa p40 subunit of mouse IL-12, either in free form, as a homodimer or when it is expressed a part of heterodimeric IL-12 and IL-23 cytokines, where it associates with p35 and p19 subunit respectively. p40 shows homology to the extracellular domain of the members of haematopoietic cytokine-receptor family. Expression of p40 is restricted to cells producing IL-12.
Additional Information: Clone REA136 displays negligible binding to Fc receptors.

Alternative names

IL12A, IL-12p35, IL-12A, Ll12a, P35, Il-12b, Il-12p40, Il12p40, P40

Technical specifications

  • Antigen: IL-12 (p40/p70)
  • Clone: REA136
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: IL12A, IL-12p35, IL-12A, Ll12a, P35, Il-12b, Il-12p40, Il12p40, P40
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: macrophages, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Oppmann, B. et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13(5): 715-725
    2. Trinchieri, G. et al. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3(2): 133-146
Product options: 2
9 µg in 300 µL (1)
EUR  28,00
30 µg in 1 mL (1)
EUR  82,00

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