Anti-IgE antibodies, human

Anti-IgE antibodies, human

Clone: REA1049 | Dilution: 1:50
Clone REA1049 recognizes the IgE isotype of human immunoglobulins. IgE is the shortest-lived immunoglobulin with a half-life of two days in serum. IgE plays an important role in allergy. It is especially associated with type 1 hypersensitivity, where IgE shows high-affinity binding to Fc receptors expressed on the surface of mast cells. Antigen binding to Fc receptor–bound IgE upon re-exposure to specific allergens results in degranulation and the release of a variety of mediators, such as histamine and cytokines.
IgE has two main receptors: the high-affinity receptor FcεRI, which is expressed only on mast cells and basophils, and the low-affinity receptor FcεRII (CD23), which is expressed on B cells.
Additional information: Clone REA1049 displays negligible binding to Fc receptors.

Technical specifications

  • Antigen: IgE
  • Clone: REA1049
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Entrez Gene ID: 3497
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: B cells, basophils, mast cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, PerCP-Vio700, VioBright 515, Biotin
Product options: 20
for 30
tests
(1)
EUR  93,00
for 100
tests
(1)
EUR  227,00
for 30
tests
(1)
EUR  113,00
for 100
tests
(1)
EUR  273,00
for 30
tests
(1)
EUR  113,00
for 100
tests
(1)
EUR  273,00
for 30
tests
(1)
EUR  118,00
for 100
tests
(1)
EUR  283,00
for 30
tests
(1)
EUR  118,00
for 100
tests
(1)
EUR  283,00
for 30
tests
(1)
EUR  124,00
for 100
tests
(1)
EUR  299,00
for 30
tests
(1)
EUR  124,00
for 100
tests
(1)
EUR  299,00
for 30
tests
(1)
EUR  124,00
for 100
tests
(1)
EUR  299,00
for 30
tests
(1)
EUR  155,00
for 100
tests
(1)
EUR  371,00
for 30
tests
(1)
EUR  93,00
for 100
tests
(1)
EUR  227,00

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