Anti-Granzyme A antibodies, human

Anti-Granzyme A antibodies, human

Clone: REA162
Clone REA162 recognizes granzyme A, a member of serine protease family expressed exclusively by cytotoxic T lymphocytes and natural killer (NK) cells. Granzyme A is a homodimeric protease and is one of the five granzymes expressed by humans. Also known as granule enzymes, granzymes comprise majority of the mass of cytolytic granules in cytotoxic T lymphocytes (CTLs) and NK cells. NK cells and γδ T cells express granzymes constitutively, whereas expression in T lymphocytes is stimulation dependent. Main function attributed to granzymes is to indue apoptotic death of infected and transformed cells. Granzymes other than granzyme B, exert relatively weaker apoptotic activity. Additional reported functions of granzyme A include, to facilitate the migration of T and NK cells and induction of cytokine secretion.
Additional information: Clone REA162 displays negligible binding to Fc receptors.

Alternative names

GZMA, CTLA-3, HFSP, Granzyme 1

Technical specifications

  • Antigen: Granzyme A
  • Clone: REA162
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: GZMA, CTLA-3, HFSP, Granzyme 1
  • Entrez Gene ID: 3001
  • Molecular mass of antigen [kDa]: 26
  • Distribution of antigen: T cells, NK cells
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. Müllbacher, A. et al. (1999) Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc. Natl. Acad. Sci. U.S.A. 96(13): 13950-13955
Product options: 1
100 µg in 100 µL
EUR  189,00