Anti-Cadherin-6 antibodies, human

Anti-Cadherin-6 antibodies, human

Clone: REA846 | Dilution: 1:50
Clone REA846 recognizes the human cadherin-6 antigen, a type I membrane-associated glycoprotein also known as K-cadherin or KCAD, which is a member of the cadherin superfamily. Cadherin-6 is found in a high level in kidney, brain, and cerebellum. It is also expressed in renal and ovariancarcinoma and in a low level in lung, pancreas, gastric mucosa, and cytotrophoblasts. Cadherins are involved in cell adhesion, forming adherens junctions. This is mediated by extracellular domains of cadherins, whereas the intracellular cytoplasmic tail associates with different adaptor and signaling proteins.
Additional information: Clone REA846 displays negligible binding to Fc receptors.

Alternative names

Kidney cadherin, K-cadherin, KCAD, Cadherin 6

Technical specifications

  • Antigen: Cadherin-6
  • Clone: REA846
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Kidney cadherin, K-cadherin, KCAD, Cadherin 6
  • Entrez Gene ID: 1004
  • Molecular mass of antigen [kDa]: 82
  • Distribution of antigen: kidney, brain, lung, ovary, pancreas
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
  • Selected references

    1. Shimoyama, Y. et al. (1999) Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin. J. Biol. Chem. 274(17): 11987-11994
    2. Shimoyama , Y. et al. (1999) Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins. Biochem. J. 274(17): 159-167
    3. Angst, B. D. et al. (2001) The cadherin superfamily: diversity in form and function. J. Cell. Sci. 114(4): 629-641
Product options: 8
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EUR  270,00
for 30
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EUR  115,00
for 100
tests
(1)
EUR  270,00
for 30
tests
(1)
EUR  95,00
for 100
tests
(1)
EUR  230,00

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